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KMID : 0369819960260040263
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Jorunal of Korean Pharmaceutical Sciences
1996 Volume.26 No. 4 p.263 ~ p.271
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Study on Preparation and Drug Release of Sulconazole Nitrate Gels
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현종목/Hyun JM
김경국/지웅길/Kim KK/Jee UK
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Abstract
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Sulconazole nitrate(SCN), an imidazole derivative which has been effective in the treatment of dermatophytosis, tinea versicolor and candidiasis, was formulated as a gel containing drug, poloxamer 407, ethanol and propylene glycol. The resulting SCN gels were evaluated with respect to their viscosity, drug release rate, skin permeation rate. The apparent viscosity of SCN gel increased in proportion to poloxamer 407, drug and propylene glycol concentration. In case ethanol was added, the apparent viscosity decreased. The drug release rate of SCN gel increased in proportion to temperature and ethanol concentration. But the drug release rate decreased as the concentration of poloxamer 407 increased. The increase of drug concentration induced nonlinear increase of drug release rate. When propylene glycol was added at the level of 10%, the drug release rate increased but from 15% it decreased. The skin permeation rate decreased in high concentration of poloxamer 407. The skin permeation rate of SCN gel containing 15% ethanol increased about twice than that of gel without ethanol. The increase of drug concentration induced nonlinear increase of skin permeation rate. When propylene glycol was added at the level of 10%, the skin permeation rate increased but from 15% it decreased.
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KEYWORD
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Sulconazole nitrate, Poloxamer, Gel, Drug release rate, Viscosity, Skin permeation rate
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